Usage: Orlishine works by blocking the enzyme that breaks down fats in your diet. This undigested fat then passes out of body in bowel movement. Orlishine does not block the absorption of calories from sugar and other non-fat foods so still need to restrict total intake of calories. Orlishine is usually taken 3 times per day with each main meal that contains some fat. May take the medicine either with your meal or up to 1 hour after eating.